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Can RTX 5090 run Qwen/Qwen2.5-72B-Instruct?

Q4 not recommended32GB VRAM availableRequires 35GB+

RTX 5090 does not meet the minimum VRAM requirement for Q4 inference of Qwen/Qwen2.5-72B-Instruct. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

RTX 5090 lacks sufficient VRAM for comfortable Qwen/Qwen2.5-72B-Instruct operation with Q4 quantization.

Your 32GB GPU is 3GB short of the 35GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q435GB32GB64.11 tok/s❌ Not recommended
Q870GB32GB38.32 tok/s❌ Not recommended
FP16141GB32GB24.20 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
153.28 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
126.76 tok/s
Price: —
AMD Instinct MI300X
192GB
107.35 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
99.80 tok/s
Price: —
NVIDIA H100 SXM5 80GB
80GB
98.56 tok/s
Price: —

More questions

RTX 5090 specs & pricingFull guide for Qwen/Qwen2.5-72B-InstructQwen/Qwen2.5-72B-Instruct speed on RTX 5090Qwen/Qwen2.5-72B-Instruct Q4 requirements