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Can NVIDIA H100 SXM5 80GB run Qwen/Qwen3.5-397B-A17B?

Q4 not recommended80GB VRAM availableRequires 222GB+

NVIDIA H100 SXM5 80GB does not meet the minimum VRAM requirement for Q4 inference of Qwen/Qwen3.5-397B-A17B. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

NVIDIA H100 SXM5 80GB lacks sufficient VRAM for comfortable Qwen/Qwen3.5-397B-A17B operation with Q4 quantization.

Your 80GB GPU is 142GB short of the 222GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q4222GB80GB59.88 tok/s❌ Not recommended
Q8444GB80GB39.76 tok/s❌ Not recommended
FP16888GB80GB22.77 tok/s❌ Not recommended

Suitable alternatives

No alternative GPUs with verified compatibility yet. Expand the compatibility import to surface more cards.

More questions

NVIDIA H100 SXM5 80GB specs & pricingFull guide for Qwen/Qwen3.5-397B-A17BQwen/Qwen3.5-397B-A17B speed on NVIDIA H100 SXM5 80GBQwen/Qwen3.5-397B-A17B Q4 requirements