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Can AMD Instinct MI300X run unsloth/Qwen3.5-397B-A17B-GGUF?

Q4 not recommended192GB VRAM availableRequires 222GB+

AMD Instinct MI300X does not meet the minimum VRAM requirement for Q4 inference of unsloth/Qwen3.5-397B-A17B-GGUF. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

AMD Instinct MI300X lacks sufficient VRAM for comfortable unsloth/Qwen3.5-397B-A17B-GGUF operation with Q4 quantization.

Your 192GB GPU is 30GB short of the 222GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q4222GB192GB100.31 tok/s❌ Not recommended
Q8444GB192GB67.69 tok/s❌ Not recommended
FP16888GB192GB37.74 tok/s❌ Not recommended

Suitable alternatives

No alternative GPUs with verified compatibility yet. Expand the compatibility import to surface more cards.

More questions

AMD Instinct MI300X specs & pricingFull guide for unsloth/Qwen3.5-397B-A17B-GGUFunsloth/Qwen3.5-397B-A17B-GGUF speed on AMD Instinct MI300Xunsloth/Qwen3.5-397B-A17B-GGUF Q4 requirements