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Can AMD Instinct MI300X run Qwen/Qwen3.5-397B-A17B?

Q4 not recommended192GB VRAM availableRequires 222GB+

AMD Instinct MI300X does not meet the minimum VRAM requirement for Q4 inference of Qwen/Qwen3.5-397B-A17B. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

AMD Instinct MI300X lacks sufficient VRAM for comfortable Qwen/Qwen3.5-397B-A17B operation with Q4 quantization.

Your 192GB GPU is 30GB short of the 222GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q4222GB192GB89.56 tok/s❌ Not recommended
Q8444GB192GB58.11 tok/s❌ Not recommended
FP16888GB192GB36.71 tok/s❌ Not recommended

Suitable alternatives

No alternative GPUs with verified compatibility yet. Expand the compatibility import to surface more cards.

More questions

AMD Instinct MI300X specs & pricingFull guide for Qwen/Qwen3.5-397B-A17BQwen/Qwen3.5-397B-A17B speed on AMD Instinct MI300XQwen/Qwen3.5-397B-A17B Q4 requirements