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Can AMD Instinct MI250X run NousResearch/Hermes-3-Llama-3.1-70B?

Runs Q4128GB VRAM availableRequires 34GB+

AMD Instinct MI250X meets the minimum VRAM requirement for Q4 inference of NousResearch/Hermes-3-Llama-3.1-70B. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

AMD Instinct MI250X can run NousResearch/Hermes-3-Llama-3.1-70B with Q4 quantization. At approximately 104 tokens/second, you can expect Excellent speed - conversational response times under 1 second.

You have 94GB headroom, which is sufficient for system overhead and smooth operation.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q434GB128GB104.43 tok/s✅ Fits comfortably
Q869GB128GB71.42 tok/s✅ Fits comfortably
FP16138GB128GB36.05 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
159.30 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
136.90 tok/s
Price: —
AMD Instinct MI300X
192GB
97.91 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
96.15 tok/s
Price: —
NVIDIA H100 SXM5 80GB
80GB
92.11 tok/s
Price: —

More questions

AMD Instinct MI250X specs & pricingFull guide for NousResearch/Hermes-3-Llama-3.1-70BNousResearch/Hermes-3-Llama-3.1-70B speed on AMD Instinct MI250XNousResearch/Hermes-3-Llama-3.1-70B Q4 requirements