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Can AMD Instinct MI210 run unsloth/Qwen3.5-397B-A17B-GGUF?

Q4 not recommended64GB VRAM availableRequires 222GB+

AMD Instinct MI210 does not meet the minimum VRAM requirement for Q4 inference of unsloth/Qwen3.5-397B-A17B-GGUF. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

AMD Instinct MI210 lacks sufficient VRAM for comfortable unsloth/Qwen3.5-397B-A17B-GGUF operation with Q4 quantization.

Your 64GB GPU is 158GB short of the 222GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q4222GB64GB30.37 tok/s❌ Not recommended
Q8444GB64GB19.43 tok/s❌ Not recommended
FP16888GB64GB10.09 tok/s❌ Not recommended

Suitable alternatives

No alternative GPUs with verified compatibility yet. Expand the compatibility import to surface more cards.

More questions

AMD Instinct MI210 specs & pricingFull guide for unsloth/Qwen3.5-397B-A17B-GGUFunsloth/Qwen3.5-397B-A17B-GGUF speed on AMD Instinct MI210unsloth/Qwen3.5-397B-A17B-GGUF Q4 requirements