L
localai.computer
ModelsGPUsSystemsAI SetupsBuildsOpenClawMethodology

Resources

  • Methodology
  • Submit Benchmark
  • About

Browse

  • AI Models
  • GPUs
  • PC Builds

Guides

  • OpenClaw Guide
  • How-To Guides

Legal

  • Privacy
  • Terms
  • Contact

© 2025 localai.computer. Hardware recommendations for running AI models locally.

ℹ️We earn from qualifying purchases through affiliate links at no extra cost to you. This supports our free content and research.

Can AMD Instinct MI210 run mistralai/Mixtral-8x22B-Instruct-v0.1?

Q4 not recommended64GB VRAM availableRequires 69GB+

AMD Instinct MI210 does not meet the minimum VRAM requirement for Q4 inference of mistralai/Mixtral-8x22B-Instruct-v0.1. Review the quantization breakdown below to see how higher precision settings impact VRAM and throughput.

What this means for you

AMD Instinct MI210 lacks sufficient VRAM for comfortable mistralai/Mixtral-8x22B-Instruct-v0.1 operation with Q4 quantization.

Your 64GB GPU is 5GB short of the 69GB minimum.

Options: (1) Try Q2 or Q3 quantization for lower VRAM requirements, (2) Consider cloud GPU rental, (3) Upgrade to a GPU with at least 16GB VRAM.

Quantization breakdown

QuantizationVRAM neededVRAM availableEstimated speedVerdict
Q469GB64GB59.80 tok/s❌ Not recommended
Q8138GB64GB43.34 tok/s❌ Not recommended
FP16275GB64GB25.38 tok/s❌ Not recommended

Suitable alternatives

AMD Instinct MI300X
192GB
204.31 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
186.56 tok/s
Price: —
AMD Instinct MI300X
192GB
143.81 tok/s
Price: —
NVIDIA H100 SXM5 80GB
80GB
128.74 tok/s
Price: —
NVIDIA H200 SXM 141GB
141GB
126.91 tok/s
Price: —

More questions

AMD Instinct MI210 specs & pricingFull guide for mistralai/Mixtral-8x22B-Instruct-v0.1mistralai/Mixtral-8x22B-Instruct-v0.1 speed on AMD Instinct MI210mistralai/Mixtral-8x22B-Instruct-v0.1 Q4 requirements